PROMPT 1 – Mr. Alvis, age 57, presented to his physician with marked fatigue, nausea with occasional diarrhea, and a sore, swollen tongue. Lately he also has been experiencing a tingling feeling in his toes and a feeling of clumsiness. Microscopic examination of a blood sample indicated a reduced number of erythrocytes, many of which are megaloblasts, and a reduced number of leukocytes, including many large, hyper segmented cells. Hemoglobin and serum levels of vitamin B12 were below normal. Additional tests confirm pernicious anemia.
Relate the pathophysiology of pernicious anemia to the manifestations listed above.
Discuss how the gastric abnormalities contribute to vitamin B12 and iron deficiency and how vitamin B12 deficiency causes complications associated with pernicious anemia.
Discuss other tests that could be performed to diagnose this type of anemia.
Discuss the treatment available and the limitations.
PROMPT 2 – Mr. Kelly is a 57-year-old man who consulted his physician after noticing marked leg pains while playing golf. He had previously noticed increasing fatigue and discomfort in his legs associated with moderate exercise. When sitting for extended periods with legs dangling, his legs became red, and sometimes his feet felt numb. His history indicates he smokes cigarettes and is chronically overweight. His blood cholesterol and other lipid levels are abnormal, and his physician suspects peripheral atherosclerosis as the cause of his discomfort.
Discuss the development of atherosclerosis, including the predisposing factors in this case and the pathophysiological changes.
Discuss the complications that might develop in this patient.
Discuss the treatments for all aspects of the patient’s condition, including slowing the progress of the atherosclerosis, maintaining circulation in the leg, and treating complications.
This assignment must be in APA format: Times Roman 12 font, double spaced, and include title and reference page.
The assignment must be in paragraph form using complete sentences and avoiding bullet points and numbered list.
Use a Level 1 heading to separate your sections (Page 62 of the APA Publication Manual).
Title and reference pages do not count toward the total word or page count.
At least two outside sources must be referenced and cited in the paper (resources must be peer reviewed from within the last 5 years)
Minimum of 300 words per prompt
LINK TO TEXTBOOK: https://ia600208.us.archive.org/24/items/Pathophsy…